Transcription-associated recombination in eukaryotes: link between transcription, replication and recombination
نویسندگان
چکیده
منابع مشابه
Transcription-associated recombination in eukaryotes: link between transcription, replication and recombination.
Homologous recombination (HR) is an important DNA repair pathway and is essential for cellular survival. It plays a major role in repairing replication-associated lesions and is functionally connected to replication. Transcription is another cellular process, which has emerged to have a connection with HR. Transcription enhances HR, which is a ubiquitous phenomenon referred to as transcription-...
متن کاملNucleoprotein structures initiating DNA replication, transcription, and site-specific recombination.
The regulated replication, recombination, and transcription of DNA require the controlled activity of unique sites in DNA. For genome replication, an origin site must be selected from 10 million or so base pairs and used precisely once for each cell division cycle. For transcription, a single regulated promoter site can exhibit differences in utilization of 1000-fold or more. In the last few ye...
متن کاملStable DNA replication: interplay between DNA replication, homologous recombination, and transcription.
Chromosome replication in Escherichia coli is normally initiated at oriC, the origin of chromosome replication. E. coli cells possess at least three additional initiation systems for chromosome replication that are normally repressed but can be activated under certain specific conditions. These are termed the stable DNA replication systems. Inducible stable DNA replication (iSDR), which is acti...
متن کاملRetroviral recombination during reverse transcription.
After mixed infection, up to half of related retroviruses are recombinants. During infection, retroviral RNA genomes are first converted to complementary DNA (cDNA) and then to double-stranded DNA. Thus recombination could occur during reverse transcription, by RNA template switching, or after reverse transcription, by breakage and reunion of DNA. It has not been possible to distinguish between...
متن کاملThe Relationship Between Replication and Recombination
DNA replication, the process of copying double-stranded DNA, and DNA recombination, the process of breaking DNA strand and joined to a different strand, are central characteristics of life. The aim of this chapter is to discuss the relationship between replication and recombination. Understanding the intimate links between these processes gives us a more holistic approach to understanding the f...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Mutagenesis
سال: 2009
ISSN: 0267-8357,1464-3804
DOI: 10.1093/mutage/gen072